The Electrocardiogram and Drug-Induced Arrhythmias
نویسندگان
چکیده
منابع مشابه
Induced Brugada-type electrocardiogram, a sign for imminent malignant arrhythmias.
Case presentation: A previously healthy 20-year-old man arrives at the emergency department for a consultation for mild fever. During his initial interview, he complains of palpitations to the triage nurse and therefore he undergoes an ECG, which is placed in the chart. A few minutes later, while awaiting his turn to be seen, he goes into cardiac arrest. The patient does not respond to resuscit...
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E lectrical activity underlies the control of the frequency, strength, and duration of contraction of the heart. During the cardiac cycle, a regular rhythmic pattern must be established in time-dependent changes in ionic conductances to ensure events that underlie normal cardiac function. Electrical impulses, originating at the sino atrial node are conducted throughout the atria until they conv...
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Drugs often have undesired side effects. In the heart, they can induce lethal arrhythmias such as torsades de pointes. The risk evaluation of a new compound is costly and can take a long time, which often hinders the development of new drugs. Here, we establish a high-resolution, multiscale computational model to quickly assess the cardiac toxicity of new and existing drugs. The input of the mo...
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Overall cardiac output (the amount of blood the heart pumps around the body every minute) is a function of how much blood the heart ejects with every beat, and the heart rate. Many factors work in concert to regulate heart rate. A thorough understanding of normal mechanisms of cardiac electrical activation and modifying factors is a necessary precursor to understanding disease states, and their...
متن کاملDrug-Induced Arrhythmias, Precision Medicine, and Small Data.
Precision medicine refers to new treatment and prevention strategies that take individual variability into account. Toward that end, the National Institutes of Health Precision Medicine Initiative envisions supporting a research program to encourage creative approaches to precision medicine, test them rigorously, and ultimately use them to build the evidence base needed to guide clinical practi...
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ژورنال
عنوان ژورنال: Kansas Journal of Medicine
سال: 2011
ISSN: 1948-2035
DOI: 10.17161/kjm.v4i3.11345